PYURF — PIGY upstream open reading frame
PYURF belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PYURF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | ATP Synthase Complex Mitochondrial & OxPhos | ATP5F1D, ATP5F1E, ATP5MC2, ATP5MC3, ATP5MF, ATP5MG, ATP5MK, ATP5PD +23 more | |
| Innate lymphoid cells | Glycolysis & OxPhos Metabolism | ARPC4, ATP6V1F, BRK1, ENO1, FKBP1A, GAPDH, NEDD8, SELENOF +2 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cyclophilin-Mediated Folding Housekeeping | B2M, BBLN, BCL7C, C12orf75, CFL1, EDF1, EIF3L, ERH +10 more |
About the gene
| Synonyms | PreY |
|---|---|
| Chromosome | 4: 88520998-88523776 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Metabolic proteins, Predicted intracellular proteins |
Function
In mitochondria, S-adenosylmethionine-dependent methyltransferase chaperone that supports both coenzyme Q biosynthesis, by stabilizing its components, such as COQ5, and NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) assembly, by stabilizing complex I assembly factors, such as NDUFAF5
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.