Protein Biogenesis & Import
Gene co-expression module in Innate lymphoid cells
| Category | Protein processing & ER |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes include PFDN5 (prefoldin subunit, chaperone for nascent polypeptides), TOMM7 (TOM complex subunit, mitochondrial protein import), SEC11A (signal peptidase complex, ER co-translational import), NACA (nascent polypeptide-associated complex, co-translational quality control), UQCRB (ubiquinol-cytochrome c reductase, Complex III), ATP6AP2 (V-ATPase accessory protein), TMEM59 (lysosomal membrane protein). KLRB1 (CD161, ILC1/NKT marker) and CD164 are immune cell markers. The module combines co-translational protein biogenesis (PFDN5, NACA, SEC11A) with mitochondrial import (TOMM7) and lysosomal/vacuolar function (ATP6AP2, TMEM59). This reflects a general protein biogenesis and trafficking program. Moderate coherence with many weak memberships is consistent with a mixed housekeeping module.
Genes
ANAPC16, ATP6AP2, CD164, COMMD6, EEF1D, KLRB1, NACA, PFDN5, S100A4, SEC11A, SNX3, TMEM59, TOMM7, UQCRB, UXT
Most correlated modules
- SUMOylation Program · correlation 0.95
- Actin Cytoskeleton Remodeling · correlation 0.93
- Innate Inflammatory Activation · correlation 0.91
- Mitochondrial Housekeeping · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.