PSMA1 — Proteasome 20S subunit alpha 1
PSMA1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PSMA1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Oxidative Phosphorylation Mitochondrial & OxPhos | ATP5MC3, ATP5MF, ATP5PB, ATP5PF, COX5A, ELOB, ERH, LDHB +8 more | View in SCUBA |
| Endothelial | Proteasomal Degradation Protein processing & ER | GNL3, HACD3, MRPL36, NME4, NUDT5, PON2, PSMB5, PSMC1 +3 more | View in SCUBA |
| Innate lymphoid cells | SUMOylation Program Protein processing & ER | ATP5MG, ATP6V1G1, BTF3, C4orf3, COX7C, EDF1, EEF1A1, HINT1 +5 more | View in SCUBA |
| Macrophages | Proteasome UPS Housekeeping | ATP6V1D, ATP6V1E1, BAX, C1orf43, COX7A2L, DCUN1D5, DNAJC15, DNAJC8 +28 more | View in SCUBA |
| Smooth muscle cells | Translocon & Proteostasis Housekeeping | ATP6V0E1, CLTA, EIF3F, NOP10, NPC2, SEC61G, ST13, SUB1 +2 more | View in SCUBA |
About the gene
| Synonyms | HC2, MGC14542, MGC14575, MGC14751, MGC1667, MGC21459, MGC22853, MGC23915, NU, PROS30 |
|---|---|
| Chromosome | 11: 14504874-14643635 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Predicted intracellular proteins |
| Biological process | Immunity |
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin- independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.