Collecting Lymphatic Identity
Gene co-expression module in Lymphatic endothelial
| Category | migration & adhesion |
|---|---|
| Genes | 22 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 15 of 22 genes have a known function matching the annotation |
Why this annotation
Hub genes RADIL, PPP1R9A, SORBS1, EPB41, CCDC141, FGD6, and ITGA6 define a cytoskeletal/focal adhesion program. EFNB2 (ephrin-B2) is a canonical collecting lymphatic/arterial identity marker; GUCY1A1 (soluble guanylate cyclase, NO-cGMP axis) and TPST2 (tyrosylprotein sulfotransferase for chemokine/selectin sulfation) are functionally linked to lymphatic valve and collecting vessel biology. PDGFD supports mural cell recruitment. WLS (Wnt secretion) and NRG3 add signaling context. Significant upregulation in CD inflammation supports a collecting lymphatic identity/remodeling program. The cytoskeletal and adhesion genes are consistent with the structural maintenance of collecting lymphatic vessels.
Genes
CCDC141, EFNB2, EPB41, FBXO34, FGD6, GUCY1A1, ITGA6, MDFIC, NAV1, NRG3, PDCD4, PDGFD, PLPP1, PPP1R9A, RADIL, RASSF8, SERPINB1, SORBS1, STXBP6, TPST2, TTN, WLS
Most correlated modules
- Innate Immune Activation · correlation 0.73
- Lymphatic Specification · correlation 0.69
- Lymphatic Valve Identity · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.