RAMP3 — Receptor activity modifying protein 3
RAMP3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RAMP3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vasoactive GPCR Signaling Endothelial cell development | APLNR, BAIAP2L1, CALCRL, COPZ2, CYSLTR1, ETS2, FAM110D, FAM167B +10 more | View in SCUBA |
| Fibroblasts | FRC function Immune interaction | ADRA2A, ANKRD29, CCL19, CCL21, CTSH, GP1BA, IL3RA, KCNK13 +3 more | View in SCUBA |
| Lymphatic endothelial | Lymphatic Valve Identity Valve formation | ALCAM, C12orf57, C17orf58, CFH, CLDN11, DEGS2, EBPL, EDNRB +13 more | View in SCUBA |
About the gene
| Chromosome | 7: 45157791-45186302 |
|---|---|
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | FDA approved drug targets, Predicted membrane proteins, Transporters |
| Molecular function | Receptor |
| Biological process | Transport |
Function
Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene- related peptide type 1 receptor (CALCRL), calcitonin receptor (CALCR) and G-protein coupled estrogen receptor 1 (GPER1). Required for the transport of CALCRL and GPER1 receptors to the plasma membrane. Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Together with CALCRL, form a receptor complex for adrenomedullin/ADM and intermedin/ADM2. Together with CALCR, act as a receptor complex for amylin/IAPP.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.