Lipid Metabolic Regulation
Gene co-expression module in Lymphatic endothelial
| Category | Lipid metabolism |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes include ZNF521 (transcriptional regulator), VAV3 and KALRN (Rho GEFs involved in cytoskeletal remodeling), EFNA5 (ephrin-A5, vascular/lymphatic patterning), PLD1 (phospholipase D, membrane remodeling), PPARG (master lipid metabolism transcription factor), CSGALNACT1 (chondroitin sulfate synthesis), TSPAN9 (tetraspanin, membrane organization), and DYSF (membrane repair). PPARG is a key regulator of lipid metabolism and is expressed in lymphatic ECs of the intestine. Multiple Rho GEFs and membrane remodeling genes suggest cytoskeletal/lipid metabolic regulation. Neighbor context with M81 (lipid/lymphatic) supports a lipid metabolism angle.
Genes
ANKS1A, CSGALNACT1, DYSF, EFNA5, KALRN, LDB2, MLLT10, PLD1, PPARG, PPP1R16B, STOX2, TSPAN9, VAV3, ZNF521
Most correlated modules
- Lymphatic EC Identity · correlation 0.97
- Hypoxia Response · correlation 0.96
- Polarized Vesicle Trafficking · correlation 0.96
- Chromatin Remodeling · correlation 0.96
- Cilia Centrosome Program · correlation 0.95
- Focal Adhesion Migration · correlation 0.94
- Lymphatic Valve Development · correlation 0.93
- Rho/Ras GTPase Regulation · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.