PPARG — Peroxisome proliferator activated receptor gamma
PPARG belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PPARG's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Leukocyte Motility migration & adhesion | ATP2A3, HSH2D, LRP12, LZTFL1, MYO1G, MYO9B, NBEAL2, TBC1D31 +1 more | View in SCUBA |
| Lymphatic endothelial | Lipid Metabolic Regulation Lipid metabolism | ANKS1A, CSGALNACT1, DYSF, EFNA5, KALRN, LDB2, MLLT10, PLD1 +5 more | View in SCUBA |
| Macrophages | Inflammatory Monocyte Activation Inflammatory | ANPEP, AQP9, CD300E, CD82, CLEC5A, CXXC5, DDX60L, DHRS9 +25 more | View in SCUBA |
About the gene
| Synonyms | NR1C3, PPARG1, PPARG2, PPARgamma |
|---|---|
| Chromosome | 3: 12287368-12434356 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Nuclear receptors, Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding, Receptor |
| Biological process | Biological rhythms, Transcription, Transcription regulation |
Function
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels (By similarity). (Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.