Chromatin Remodeling
Gene co-expression module in Lymphatic endothelial
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes include MPDZ (multi-PDZ domain scaffold for tight junctions/polarity), REV3L (DNA polymerase zeta, DNA damage repair), BAZ2B (bromodomain chromatin remodeler), SETX (senataxin, RNA-DNA helicase, transcription termination/DNA repair), SENP7 (SUMO-specific protease, chromatin regulation), CHD9 (chromatin helicase DNA binding), JMJD1C (histone H3K9 demethylase), RBMS1 (RNA binding). The predominance of chromatin remodeling and DNA/RNA processing genes (BAZ2B, CHD9, JMJD1C, SENP7, SETX, REV3L, RBMS1) defines this as a chromatin/epigenetic regulation module. PACSIN2 (endocytosis) and PLXDC2 are peripheral members.
Genes
BAZ2B, CHD9, ITFG1, JMJD1C, MICAL3, MPDZ, PACSIN2, PHKB, PLXDC2, RBMS1, REV3L, SENP7, SETX
Most correlated modules
- Lipid Metabolic Regulation · correlation 0.96
- Hypoxia Response · correlation 0.96
- Cilia Centrosome Program · correlation 0.95
- Endosomal Vesicle Trafficking · correlation 0.95
- Lymphatic EC Identity · correlation 0.94
- Polarized Vesicle Trafficking · correlation 0.94
- Focal Adhesion Migration · correlation 0.94
- Rho/Ras GTPase Regulation · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.