Focal Adhesion Migration
Gene co-expression module in Lymphatic endothelial
| Category | migration & adhesion |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes PTK2 (FAK), DOCK1 (Rac1 GEF), LPP (focal adhesion LIM protein), CDC42BPA (MRCK-alpha), and NF1 (RasGAP) collectively define a focal adhesion and cell migration program. GNAQ links to upstream Gq signaling driving cytoskeletal remodeling. TCF12 and BIRC6 are peripheral but consistent with a migratory/survival program in LECs. This module is a topological neighbor of M91 (which contains ELMO1, the canonical DOCK1 co-activator), strongly reinforcing a DOCK1/Rac1-mediated migration axis.
Genes
BIRC6, CDC42BPA, DOCK1, EIF4G3, GNAQ, LPP, NF1, PAM, PTK2, TCF12, WDFY3
Most correlated modules
- Rho/Ras GTPase Regulation · correlation 0.97
- Polarized Vesicle Trafficking · correlation 0.97
- Cilia Centrosome Program · correlation 0.97
- Actin-based Migration · correlation 0.97
- Hippo-Adhesion Signaling · correlation 0.95
- Chromatin Remodeling · correlation 0.95
- Inflammatory cAMP Response · correlation 0.95
- Chromatin Remodeling · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.