Hypoxia Response
Gene co-expression module in Lymphatic endothelial
| Category | Stress |
|---|---|
| Genes | 20 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include KAT2B (histone acetyltransferase/epigenetic), HIF3A (hypoxia-inducible factor 3A, dominant hypoxia signal), RUNX1T1 (transcriptional co-repressor), NTN1 (netrin-1, vessel/lymphatic guidance), SPTLC2 (serine palmitoyltransferase, sphingolipid synthesis), FOXP2 (transcription factor), MAP3K1 (MAPK kinase), FBN1 (fibrillin-1, ECM), FKBP5 (glucocorticoid/stress response). HIF3A is the dominant hub and acts as a negative regulator of hypoxia response. NTN1 is involved in lymphangiogenesis. The combination of HIF3A, KAT2B, and RUNX1T1 suggests a hypoxia-responsive transcriptional program. SPTLC2 and FBN1 are peripheral ECM/metabolic members.
Genes
CNTNAP3B, ENOSF1, FBN1, FKBP5, FOXP2, HIF3A, HMCN1, KAT2B, MAP3K1, NTN1, PDE1A, PKHD1L1, PLCE1, PTPN3, RAPGEF4, RUNX1T1, SHANK3, SNRK, SPTLC2, TMTC1
Most correlated modules
- Lipid Metabolic Regulation · correlation 0.96
- Chromatin Remodeling · correlation 0.96
- Polarized Vesicle Trafficking · correlation 0.94
- Lymphatic Valve Development · correlation 0.93
- Lymphatic EC Identity · correlation 0.93
- Cilia Centrosome Program · correlation 0.92
- Endothelial Receptor Signaling · correlation 0.91
- Endosomal Vesicle Trafficking · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.