Polarized Vesicle Trafficking
Gene co-expression module in Lymphatic endothelial
| Category | migration & adhesion |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 14 genes have a known function matching the annotation |
Why this annotation
ELMO1 is the canonical co-activator of DOCK1 (hub of neighbor M66), forming the ELMO-DOCK bimodular Rac1 GEF complex — this directly links M91 to M66. EXOC4 and EXOC6B are exocyst complex subunits mediating vesicle tethering and polarized secretion. PARD3B encodes a Par3 polarity scaffold. VPS13B and LRBA are large vesicle-trafficking regulators. MYO9A is a myosin with RhoGAP activity. Together these genes describe polarized vesicle trafficking and cell polarity downstream of Rac1/Rho signaling in LECs.
Genes
ELMO1, EXOC4, EXOC6B, IMMP2L, L3MBTL4, LRBA, LRMDA, MYO9A, PARD3B, PRKN, SCAPER, ST6GALNAC3, VPS13B, WWOX
Most correlated modules
- Cilia Centrosome Program · correlation 0.98
- Focal Adhesion Migration · correlation 0.97
- Rho/Ras GTPase Regulation · correlation 0.97
- Lipid Metabolic Regulation · correlation 0.96
- Inflammatory cAMP Response · correlation 0.95
- Actin-based Migration · correlation 0.95
- Chromatin Remodeling · correlation 0.94
- Hypoxia Response · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.