Chromatin Remodeling
Gene co-expression module in Lymphatic endothelial
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 11 genes have a known function matching the annotation |
Why this annotation
KDM6A (H3K27me3 demethylase), KMT2C (H3K4 methyltransferase), MED13L (Mediator complex subunit), DYRK1A (kinase phosphorylating chromatin regulators), NCOA1 (nuclear receptor coactivator), and MRTFA (MAL/MKL1, SRF coactivator linking actin to transcription) collectively define a chromatin remodeling and transcriptional coactivation program. MBNL1 adds RNA splicing regulation. USP34 and HERC1 are ubiquitin regulators that modulate chromatin factor stability. This is a broad epigenetic regulatory module. Neighbor context: M45 also features chromatin regulators (ASH1L, WAC, SETD5, NIPBL), suggesting a neighborhood of epigenetic regulatory programs in LECs.
Genes
DYRK1A, HERC1, KDM6A, KMT2C, MBNL1, MED13L, MRTFA, NCOA1, PDE8A, PEAK1, USP34
Most correlated modules
- Hippo-Adhesion Signaling · correlation 0.97
- MAPK-ERK Signaling · correlation 0.96
- Actin-based Migration · correlation 0.96
- ZEB1-driven EMT · correlation 0.96
- Rho/Ras GTPase Regulation · correlation 0.95
- Focal Adhesion Migration · correlation 0.95
- Inflammatory cAMP Response · correlation 0.92
- Cilia Centrosome Program · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.