Actin Cytoskeletal Dynamics
Gene co-expression module in Lymphatic endothelial
| Category | Cytoskeletal |
|---|---|
| Genes | 8 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 8 genes have a known function matching the annotation |
Why this annotation
ACTN1 (alpha-actinin-1, actin filament crosslinker and focal adhesion component) is the top hub, followed by NAV2 (neuron navigator 2, microtubule plus-end tracking and cell migration), SYNJ2 (synaptojanin-2, phosphoinositide phosphatase regulating membrane-cytoskeleton dynamics), and PIK3C2B (class II PI3K, membrane trafficking and cytoskeletal regulation). PRRC2C links to RNA-binding/stress granules. The module is small (8 genes) with mixed signals, but the cytoskeletal/membrane dynamics theme is dominant. BMAL2 (circadian) and PFKP (glycolysis) are peripheral members that reduce coherence.
Genes
ACTN1, BMAL2, NAV2, PFKP, PIK3C2B, PRRC2C, SLC39A14, SYNJ2
Most correlated modules
- TBK1-JAK Immune Signaling · correlation 0.89
- NRF2 Oxidative Stress · correlation 0.82
- NF-κB Inflammatory Activation · correlation 0.81
- Apoptosis Immune Regulation · correlation 0.80
- Basement Membrane ECM · correlation 0.78
- Hypoxia HIF Response · correlation 0.72
- Stress Kinase Signaling · correlation 0.71
- Genotoxic Innate Inflammation · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.