NF-κB Inflammatory Activation
Gene co-expression module in Lymphatic endothelial
| Category | Inflammation |
|---|---|
| Genes | 18 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 18 genes have a known function matching the annotation |
Why this annotation
NFKB2, TNIP1, TNFAIP2, TNFAIP8 are canonical NF-κB pathway components and targets. CXCL1 and CXCL8 are NF-κB-driven inflammatory chemokines. NOD2 is a pattern recognition receptor that activates NF-κB. SERPINE1 (PAI-1) and SOD2 are NF-κB targets. ICOSLG is an immune co-stimulatory ligand. Significantly upregulated in CD inflammation. This is a strong canonical NF-κB inflammatory activation module in intestinal lymphatic endothelial cells.
Genes
ACHE, ANKLE2, CD200, CXCL1, CXCL8, HMGA1, ICOSLG, NFKB2, NOD2, RANGAP1, SERPINE1, SLC12A7, SLC43A3, SOD2, STAT5A, TNFAIP2, TNFAIP8, TNIP1
Most correlated modules
- Apoptosis Immune Regulation · correlation 0.91
- AhR mRNA Regulation · correlation 0.86
- NF-κB Autophagy Regulation · correlation 0.85
- Stress Kinase Signaling · correlation 0.83
- Genotoxic Innate Inflammation · correlation 0.82
- Actin Cytoskeletal Dynamics · correlation 0.81
- Integrated Stress Response · correlation 0.80
- NF-κB Negative Feedback · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.