Apoptosis Immune Regulation
Gene co-expression module in Lymphatic endothelial
| Category | Immune regulation |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
OPTN (optineurin) is an NF-κB and autophagy regulator; CFLAR (c-FLIP) inhibits apoptosis/necroptosis; PAWR (Par-4) promotes apoptosis; TAP1 is an IFN-γ-induced antigen presentation gene; NINJ1 mediates plasma membrane rupture in inflammatory cell death; GRINA is involved in cell death signaling. Significant delta_inflammation_CD. The module reflects a balance of pro- and anti-apoptotic signals with interferon-responsive antigen presentation, consistent with inflammatory cell survival regulation in LECs. Neighbor to M4 (NF-κB activation) supports inflammatory context.
Genes
A4GALT, CFLAR, COX17, GRINA, MPZL1, NINJ1, OPTN, PAWR, RCN1, TAP1, UBE2Z
Most correlated modules
- NF-κB Inflammatory Activation · correlation 0.91
- Genotoxic Innate Inflammation · correlation 0.89
- Hypoxia HIF Response · correlation 0.84
- Oxidative Stress Response · correlation 0.81
- NF-κB Autophagy Regulation · correlation 0.80
- AhR mRNA Regulation · correlation 0.80
- Actin Cytoskeletal Dynamics · correlation 0.80
- Proteasome Assembly · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.