NRF2 Oxidative Stress
Gene co-expression module in Lymphatic endothelial
| Category | Stress |
|---|---|
| Genes | 20 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
NFE2L2 (NRF2) is the master transcriptional regulator of oxidative stress response and is the second-ranked hub. DRAM1 (autophagy/DNA damage), GCH1 (tetrahydrobiopterin/NO homeostasis), PNPLA8 (mitochondrial phospholipase, oxidative lipid metabolism), PSMD11 (proteasome subunit for proteostasis), and VAPA (ER membrane contacts) support an NRF2-driven oxidative stress and proteostasis program. Neighbor M49 also contains stress-response genes (MAPKAPK2, MAFG), reinforcing this as a related oxidative/cellular stress module.
Genes
B4GALT1, CTTNBP2NL, DDX21, DRAM1, GCH1, HNRNPF, MSN, NFE2L2, PDXDC1, PNP, PNPLA8, PSMD11, RAP1B, RDX, RNF115, SLC7A1, STAG2, TFG, TUBA1C, VAPA
Most correlated modules
- TBK1-JAK Immune Signaling · correlation 0.86
- Actin Cytoskeletal Dynamics · correlation 0.82
- NF-κB Autophagy Regulation · correlation 0.82
- Stress Kinase Signaling · correlation 0.79
- NRF2 Oxidative Stress · correlation 0.78
- Integrated Stress Response · correlation 0.77
- DNA Damage Apoptosis · correlation 0.76
- Basement Membrane ECM · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.