Translation Elongation
Gene co-expression module in Lymphatic endothelial
| Category | RNA processing & translation |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes: PTMA (prothymosin alpha, chromatin remodeling/nuclear), EEF1A1 (elongation factor 1-alpha, translation), HNRNPA1 (heterogeneous nuclear ribonucleoprotein, RNA processing), EEF2 (elongation factor 2, translation), EIF1 (translation initiation factor), TUBA1B (tubulin alpha, cytoskeleton), FTH1/FTL (ferritin heavy/light chains, iron storage), SBDS (ribosome biogenesis/Shwachman-Bodian-Diamond), HNRNPA0 (RNA processing), ANXA2 (annexin A2, membrane/cytoskeleton). The module is dominated by translation elongation factors (EEF1A1, EEF2, EIF1), RNA-binding proteins (HNRNPA1, HNRNPA0), and ribosome biogenesis (SBDS). FTH1/FTL add iron homeostasis. This is a core translational machinery / housekeeping module with high mean expression (2.332) and high pct positive (82.5%), consistent with constitutive housekeeping activity. Neighbor context: highest expressed module in the batch, consistent with housekeeping translation.
Genes
ANXA2, EEF1A1, EEF2, EIF1, FTH1, FTL, HNRNPA0, HNRNPA1, PTMA, SBDS, TUBA1B
Most correlated modules
- mRNA Translation Regulation · correlation 0.95
- Actomyosin Cytoskeleton · correlation 0.89
- RNA Protein Homeostasis · correlation 0.84
- MHC-I Antigen Presentation · correlation 0.82
- Oxidative Stress Response · correlation 0.80
- Integrated Stress Response · correlation 0.73
- 20S Proteasome Core · correlation 0.73
- Protein Quality Control · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.