Oxidative Stress Response
Gene co-expression module in Lymphatic endothelial
| Category | Stress |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes include ANXA5 (annexin V, phosphatidylserine binding, apoptosis), TXN (thioredoxin, redox/antioxidant), GPX4 (glutathione peroxidase 4, ferroptosis defense/lipid peroxide reduction), S100A11 (calcium-binding stress protein), NUPR1 (stress-responsive nuclear protein, ER/oxidative stress), CD59 (complement regulatory protein), EIF5A (translation factor with hypusination, stress response), DRAP1 (transcriptional repressor), PFDN2 (prefoldin chaperone), CCT3 (chaperonin complex), PDLIM4 (actin cytoskeleton), ATP6V0B (vacuolar ATPase). The combination of GPX4, TXN, NUPR1, ANXA5, and S100A11 strongly points to an oxidative/ferroptosis stress-resistance program. GPX4 is the canonical ferroptosis suppressor; TXN and NUPR1 are co-induced under oxidative and ER stress. ANXA5 marks apoptotic/stressed cells. This module reflects a cellular oxidative stress and ferroptosis-resistance program rather than a single canonical pathway. Neighbor context: sits near proteasome (M55, M42) and housekeeping (M26) modules, consistent with a general stress/proteostasis neighborhood.
Genes
ANXA5, ATP6V0B, CCT3, CD59, DRAP1, EIF5A, GPX4, NUPR1, PDLIM4, PFDN2, S100A11, TXN
Most correlated modules
- RNA Protein Homeostasis · correlation 0.92
- Proteasome Assembly · correlation 0.90
- mRNA Translation Regulation · correlation 0.88
- Apoptosis Immune Regulation · correlation 0.81
- Translation Elongation · correlation 0.80
- MHC-I Antigen Presentation · correlation 0.80
- Hypoxia HIF Response · correlation 0.80
- NF-κB Autophagy Regulation · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.