SCUBA

RHOC — Ras homolog family member C

RHOC belongs to a gene co-expression module in 13 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

RHOC's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsInflammatory effector
Immune regulation
C3AR1, CAST, CLDND1, CMTM3, CREB3L2, EIF4E3, EPB41, FYCO1 +9 moreView in SCUBA
CD8⁺ T cellsGut Tissue Residency
Gut residence
ALOX5AP, C4orf3, CAPN2, CD164, CD3D, CD7, CD99, CLIC3 +9 moreView in SCUBA
EndothelialVascular Tone Regulation
Endothelial cell development
ADAMTS6, ATP1A1, ATP1B3, ATP5PF, CALD1, CAVIN3, CCDC3, CD81 +13 moreView in SCUBA
FibroblastsRho GTPase Cytoskeletal
Cytoskeletal
APRT, CLIC1, CYBA, HSBP1, LY6E, RAB34, RHOA, S100A11 +2 moreView in SCUBA
Gamma-delta T cellsActin-based Motility
Cytoskeletal
APBB1IP, CD58, COMMD7, CORO1B, CTSD, EVL, FDFT1, HMOX2 +13 more
Glial cellsGlutathione Detoxification
Stress
DAD1, GSTP1, ITM2B, MGST3, RABAC1, SRP14, TMA7, VIM +1 moreView in SCUBA
Goblet cellsS100 Calcium Signaling
Stress
CIB1, CLDN7, CLTB, GUK1, MYL12B, MYL6, S100A11, S100A13 +4 moreView in SCUBA
Innate lymphoid cellsActin Cytoskeleton Dynamics
Cytoskeleton & motility
ACTB, ACTG1, ACTR3, ANAPC11, AP2S1, ARPC5, CALM3, CAPZB +11 moreView in SCUBA
Lymphatic endothelialMHC-I Antigen Presentation
Immune regulation
ATP6V1F, HLA-A, HLA-B, HLA-C, HLA-E, OAZ1, PPP1R14B, PSMB8 +2 moreView in SCUBA
MacrophagesInflammatory Monocyte Activation
Inflammatory
ACTN1, ADAM8, AGTRAP, ANXA2, ANXA4, C15orf48, CD44, CD9 +21 moreView in SCUBA
MonocytesNon-classical Monocyte
Innate immunity
CD79B, CDH23, CDKN1C, CHST7, CKB, CYFIP2, KNDC1, LYPD2 +6 moreView in SCUBA
Natural Killer cellsNK Cytotoxic Activation
Cytotoxicity
ABI3, ALOX5AP, ARHGDIB, BPGM, CD247, GNPTAB, GZMA, HCLS1 +3 moreView in SCUBA
Smooth muscle cellsRho GTPase Housekeeping
Housekeeping
CDC42, CST3, DDT, OST4, POLR2L, PRELID1, SCAND1View in SCUBA

About the gene

SynonymsARH9, ARHC
Chromosome1: 112701127-112707434
Predicted locationIntracellular
Essential geneNo
Protein classCancer-related genes, Predicted intracellular proteins

Function

Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.