Nuclear Receptor Chromatin
Gene co-expression module in Mucosal-associated invariant T cell
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include PHF1 (PRC2/H3K27me3 chromatin), NR1H2 (LXR-beta nuclear receptor), FBRS (chromatin remodeling), DDX39A and DDX21 (RNA helicases involved in transcription-coupled RNA processing), GNL1 (ribosome biogenesis GTPase), and SQSTM1 (autophagy receptor/NF-κB scaffold). The dominant theme is chromatin and transcriptional regulation, with PHF1 as a PRC2 accessory subunit, NR1H2 as a nuclear receptor, and FBRS as a chromatin factor. DDX39A and DDX21 support RNA processing at the transcription interface. CD8A presence is consistent with MAIT identity. Core coherence supports a unified program centered on chromatin/nuclear receptor-mediated gene regulation.
Genes
CD8A, DDX21, DDX39A, FBRS, GNL1, NR1H2, PHF1, SQSTM1, TRABD, TSEN54
Most correlated modules
- mRNA 3' Processing · correlation 0.87
- Stress Granule Response · correlation 0.84
- Retinoic Acid Response · correlation 0.84
- mRNA Decay Program · correlation 0.83
- Housekeeping Translation · correlation 0.82
- Transcriptional Co-regulation · correlation 0.81
- Co-transcriptional Splicing · correlation 0.80
- NF-κB Negative Feedback · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.