Housekeeping Translation
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Housekeeping |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 13 genes have a known function matching the annotation |
Why this annotation
High mean expression (1.877) and 83.2% detection indicate broadly expressed housekeeping genes. Hub ARHGDIA (Rho-GDI alpha, ubiquitously expressed cytoskeletal regulator), PABPC1 (poly-A binding protein, core translation), EEF2 (elongation factor 2, housekeeping translation), HNRNPA1 (core RNA binding), SF1 (splicing/branch point recognition), DAZAP2 (RNA binding), RBMX, SRRM1 (splicing). HLA-A and HLA-B are constitutively expressed MHC class I molecules. CCNI (cyclin I, constitutively expressed), SEPTIN9 (cytoskeletal), ARHGEF1 (Rho GEF). The module represents constitutively expressed housekeeping functions: translation elongation, RNA binding/splicing, and cytoskeletal regulation at high uniform expression.
Genes
ARHGDIA, ARHGEF1, CCNI, DAZAP2, EEF2, HLA-A, HLA-B, HNRNPA1, PABPC1, RBMX, SEPTIN9, SF1, SRRM1
Most correlated modules
- Co-transcriptional Splicing · correlation 0.84
- Nuclear Receptor Chromatin · correlation 0.82
- mRNA 3' Processing · correlation 0.78
- NF-κB RNA Regulation · correlation 0.77
- TGF-beta Response · correlation 0.74
- RNA Splicing m6A · correlation 0.74
- mRNA Processing Translation · correlation 0.72
- Retinoic Acid Response · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.