Retinoic Acid Response
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Tissue residence |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
RARA (retinoic acid receptor alpha) is the central transcription factor for retinoic acid signaling, which governs tissue homing and T cell differentiation. NDRG1 is a retinoic acid and hypoxia target. EHD1 and RALGDS are involved in vesicular trafficking downstream of receptor signaling. PERP is a p53/p63 target associated with apoptosis or differentiation. CHRAC1 is a chromatin remodeling factor. The module is small (8 genes) and moderately coherent; RARA + NDRG1 anchor a retinoic acid response program relevant to MAIT tissue residence.
Genes
C16orf54, CHRAC1, EHD1, MRPL10, NDRG1, PERP, RALGDS, RARA
Most correlated modules
- Nuclear Receptor Chromatin · correlation 0.84
- Stress Granule Response · correlation 0.83
- Anti-inflammatory Homing · correlation 0.82
- NF-κB Negative Feedback · correlation 0.81
- BMP/TGF-β Inhibitory · correlation 0.79
- RNA Processing Stress · correlation 0.78
- mRNA Decay Program · correlation 0.78
- AP-1/MEF2 Activation · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.