DDX39A — DExD-box helicase 39A
DDX39A belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DDX39A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | ER stress UPR Protein processing & ER | CCT2, CDK2AP2, CRELD2, DNAJB11, DSTN, EIF5A, GPSM3, GTF3A +9 more | View in SCUBA |
| CD8⁺ T cells | Mitotic Spindle Cell cycle | ASF1B, CENPN, DTYMK, GGH, HMGB2, HMGN2, LMNB1, STMN1 +3 more | View in SCUBA |
| Gamma-delta T cells | mRNA Splicing & Trafficking RNA processing & translation | ARF1, ARL6IP1, ARRDC2, B3GNT2, C17orf49, CCDC12, CWC15, EIF5A +19 more | |
| Goblet cells | Pyroptosis Stress Response Stress | ADAM15, AURKAIP1, CDC37, CENPX, COMTD1, EEF1D, GSDMD, INF2 +6 more | View in SCUBA |
| Mucosal-associated invariant T cell | Nuclear Receptor Chromatin DNA/chromatin regulation | CD8A, DDX21, FBRS, GNL1, NR1H2, PHF1, SQSTM1, TRABD +1 more |
About the gene
| Synonyms | BAT1L, DDX39, DDXL, URH49 |
|---|---|
| Chromosome | 19: 14408798-14419383 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Helicase, Hydrolase, RNA-binding |
| Biological process | mRNA processing, mRNA splicing |
Function
Helicase that plays an essential role in mRNA export and is involved in multiple steps in RNA metabolism including alternative splicing. Regulates nuclear mRNA export to the cytoplasm through association with ECD. Also involved in spliceosomal uridine-rich small nuclear RNA (U snRNA) export by stimulating the RNA binding of adapter PHAX. Plays a role in the negative regulation of type I IFN production by increasing the nuclear retention of antiviral transcripts and thus reducing their protein expression. Independently of the interferon pathway, plays an antiviral role against alphaviruses by binding to a 5' conserved sequence element in the viral genomic RNA.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.