Stress Granule Response
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Stress |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
Top hub G3BP2 is a canonical stress granule nucleator and RNA-binding protein central to the integrated stress response. HNRNPUL1 is an RNA-binding protein involved in stress granule formation and RNA metabolism. BZW1 supports translation initiation. MAPK1IP1L scaffolds MAPK signaling. MAP3K8 (TPL2) is a stress-activated kinase. CRTC2 is a CREB coactivator regulated by stress. RNF138 is a ubiquitin ligase. EZR (ezrin) links membrane to cytoskeleton. YWHAZ (14-3-3ζ) is a signaling scaffold. HERPUD2 is an ER stress protein. The module centers on stress granule biology and integrated stress response signaling.
Genes
BZW1, CRTC2, EZR, G3BP2, HERPUD2, HNRNPUL1, MAP3K8, MAPK1IP1L, RNF138, SPOCK2, SPTY2D1, YWHAZ
Most correlated modules
- AP-1/MEF2 Activation · correlation 0.92
- RNA Processing Stress · correlation 0.91
- NF-κB Negative Feedback · correlation 0.88
- NF-κB Activation · correlation 0.87
- T cell Quiescence · correlation 0.85
- Nuclear Receptor Chromatin · correlation 0.84
- Co-transcriptional Splicing · correlation 0.84
- Retinoic Acid Response · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.