NF-κB Negative Feedback
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Immune regulation |
|---|---|
| Genes | 16 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes TNFAIP3, NFKBIA, and NFKBIB are canonical NF-κB inhibitors forming a negative feedback loop after activation. TSC22D3 (GILZ) is glucocorticoid-induced and suppresses NF-κB. ZFP36 destabilizes cytokine mRNAs post-activation. NR4A2 and CSRNP1 are activation-induced transcription factors that dampen inflammation. CXCR4 links to post-activation migration. PTGER4 mediates prostaglandin-driven immunosuppression. Together this is a coherent NF-κB negative feedback / post-activation resolution program.
Genes
ARL4A, BCAS2, CSRNP1, CXCR4, ENSG00000285976, IDS, ITPRIP, NFKBIA, NFKBIB, NR4A2, PTGER4, SBDS, TENT5C, TNFAIP3, TSC22D3, ZFP36
Most correlated modules
- RNA Processing Stress · correlation 0.92
- mRNA Decay Program · correlation 0.91
- T cell Activation · correlation 0.90
- Integrated Stress Response · correlation 0.90
- NF-κB Activation · correlation 0.89
- Dissociation Stress Response · correlation 0.89
- Stress Granule Response · correlation 0.88
- AP-1/MEF2 Activation · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.