mRNA Decay Program
Gene co-expression module in Mucosal-associated invariant T cell
| Category | RNA processing & translation |
|---|---|
| Genes | 22 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 22 genes have a known function matching the annotation |
Why this annotation
Hub genes ZFP36L2 (TTP family RNA-binding protein that destabilizes mRNAs via ARE), BTG1 and BTG3 (anti-proliferative mRNA deadenylation cofactors), EXOSC6 (RNA exosome subunit for mRNA decay), RBBP6 (involved in RNA 3' end processing and mRNA decay), HNRNPL (splicing/mRNA stability), SNRPA1 (spliceosome), DDIT4/REDD1 (mTOR inhibitor, stress response), SIAH2 (E3 ubiquitin ligase), BCL7B (chromatin), DYNLL2 (dynein), ATP6V0C (lysosomal V-ATPase), FTH1 (ferritin). The module is dominated by mRNA decay machinery (ZFP36L2, BTG1, BTG3, EXOSC6) alongside stress/metabolic elements, indicating post-transcriptional gene silencing as the core program.
Genes
ATP6V0C, BCL7B, BTG1, BTG3, CCDC59, DDIT4, DUSP2, DYNLL2, EXOSC6, FTH1, HNRNPL, LEPROTL1, MED30, NSMCE3, RBBP6, SARAF, SIAH2, SLC35E1, SNRPA1, SOCS1, YRDC, ZFP36L2
Most correlated modules
- NF-κB Negative Feedback · correlation 0.91
- Transcriptional Co-regulation · correlation 0.89
- AP-1/MEF2 Activation · correlation 0.89
- Dissociation Stress Response · correlation 0.83
- Nuclear Receptor Chromatin · correlation 0.83
- Stress Granule Response · correlation 0.83
- Integrated Stress Response · correlation 0.81
- NF-κB Activation · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.