PHF1 — PHD finger protein 1
PHF1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PHF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Integrated Stress Response Stress | AMD1, DDIT3, FAM133B, GOLGB1, IFRD1, MIDN, MKNK2, PIM2 +4 more | View in SCUBA |
| Gamma-delta T cells | Stress Epigenetic Silencing DNA/chromatin regulation | ALKBH5, ANKHD1, EPC2, FAM53C, MXD1, NEU1, OTUD4, PNO1 +8 more | |
| Innate lymphoid cells | NF-κB Inflammatory Activation Inflammation | CDKN1A, CSRNP1, DUSP1, DUSP2, DUSP6, ELL2, EZR, FOS +26 more | View in SCUBA |
| Macrophages | Transcriptional Elongation Housekeeping | AKIRIN1, ATF4, ATXN2L, CCDC82, CDK9, CHMP1A, CLCN7, EIF5 +19 more | View in SCUBA |
| Mucosal-associated invariant T cell | Nuclear Receptor Chromatin DNA/chromatin regulation | CD8A, DDX21, DDX39A, FBRS, GNL1, NR1H2, SQSTM1, TRABD +1 more |
About the gene
| Synonyms | MTF2L2, PCL1, TDRD19C |
|---|---|
| Chromosome | 6: 33410399-33416453 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Chromatin regulator, Repressor |
| Biological process | DNA damage, Transcription, Transcription regulation |
Function
Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci. According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2. Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.