ATP Synthase Complex
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 12 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 7 of 12 genes have a known function matching the annotation |
Why this annotation
The module is dominated by ATP synthase subunits: ATP5ME (subunit e/g), ATP5F1E (subunit epsilon, F1), ATP5MK (subunit k), and supported by NDUFA1 (Complex I), UQCR11 (Complex III), COX7C (Complex IV), HAX1 (mitochondrial anti-apoptotic). COPS9 (COP9 signalosome) and COMMD6/RBIS/ARL6IP4 are peripheral. TMA7 is a translation factor. Core coherence with near-uniform expression across all genes firmly places this as a tight OxPhos/ATP synthase module. This is the most focused ETC module in the batch.
Genes
ARL6IP4, ATP5F1E, ATP5ME, ATP5MK, COMMD6, COPS9, COX7C, HAX1, NDUFA1, RBIS, TMA7, UQCR11
Most correlated modules
- ER Glycosylation & Ubiquitin · correlation 0.88
- Cyclophilin-Mediated Folding · correlation 0.82
- Antigen Processing · correlation 0.81
- Mitochondrial Metabolism & Redox · correlation 0.79
- Mitochondrial Housekeeping · correlation 0.78
- Mitochondrial OxPhos · correlation 0.78
- RNA Biogenesis & Folding · correlation 0.78
- NADPH Oxidase & Innate Immune · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.