ER Glycosylation & Ubiquitin
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Protein processing & ER |
|---|---|
| Genes | 18 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 14 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes: KRTCAP2 (keratinocyte-associated protein 2 — ER), ELOB (elongin B — ubiquitin E3 ligase component), COX6B1/COX6A1 (Complex IV subunits), NEDD8 (neddylation — cullin-RING ubiquitin ligase activation), TMEM258 (ER membrane, N-glycosylation complex), AIP (aryl hydrocarbon receptor interacting protein — chaperone), OST4 (oligosaccharyltransferase subunit — N-glycosylation), MYL6 (myosin light chain), ATP5MG/NDUFB2/NDUFA7 (OxPhos), GAPDH/ALDOA (glycolysis), FIS1 (mitochondrial fission), NME2 (nucleoside diphosphate kinase), MIF (macrophage migration inhibitory factor). The ER glycosylation machinery (TMEM258, OST4, KRTCAP2) and ubiquitin pathway (ELOB, NEDD8) are prominent alongside OxPhos subunits. The dominant theme is ER protein processing/glycosylation with metabolic support.
Genes
AIP, ALDOA, ATP5MG, COX6A1, COX6B1, ELOB, FIS1, GAPDH, KRTCAP2, MIF, MYL6, NDUFA7, NDUFB2, NEDD8, NME2, OST4, TMEM258, WDR83OS
Most correlated modules
- NADPH Oxidase & Innate Immune · correlation 0.88
- ATP Synthase Complex · correlation 0.88
- Cyclophilin-Mediated Folding · correlation 0.88
- Mitochondrial Metabolism & Redox · correlation 0.88
- RNA Biogenesis & Folding · correlation 0.85
- Immunoproteasome Activity · correlation 0.83
- Antigen Processing · correlation 0.80
- Mitochondrial OxPhos · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.