Mitochondrial Housekeeping
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 16 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 3 of 16 genes have a known function matching the annotation |
Why this annotation
Top hub genes NDUFB10 (Complex I subunit) and UQCR10 (Complex III subunit) are core OxPhos components. TUFM encodes mitochondrial elongation factor Tu required for mitochondrial translation. Additional genes (VPS28, ARPC3, ZYX, GNB2, SSNA1, PLEKHJ1, LSM2) are general housekeeping/cytoskeletal but the mitochondrial respiratory chain genes dominate by PageRank and membership. Core coherence with uniform expression supports a constitutively expressed housekeeping program anchored in mitochondrial function.
Genes
ARPC3, DUT, GNB2, GPSM3, LSM2, NAA38, NDUFB10, PLEKHJ1, REX1BD, SSNA1, THAP11, TNFSF12, TUFM, UQCR10, VPS28, ZYX
Most correlated modules
- Leukocyte Housekeeping · correlation 0.94
- T cell Identity · correlation 0.91
- Mitochondrial OxPhos · correlation 0.91
- T cell Homeostasis · correlation 0.90
- T cell Surface Signaling · correlation 0.87
- Mitochondrial Biogenesis · correlation 0.84
- ER & Mitochondrial Assembly · correlation 0.84
- Oxidative Stress Response · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.