Cyclophilin-Mediated Folding
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Housekeeping |
|---|---|
| Genes | 19 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes: PPIA and PPIB (peptidyl-prolyl isomerases/cyclophilins — protein folding chaperones), CFL1 (cofilin — actin dynamics), MYL12B (non-muscle myosin light chain), EIF3L (eukaryotic translation initiation factor 3L), NDUFB7/NDUFB11 (Complex I), IL32 (pro-inflammatory cytokine, T cell-expressed), B2M (beta-2-microglobulin — MHC-I), SSR2 (signal recognition particle receptor), LSP1 (lymphocyte-specific protein 1 — actin binding). The module blends protein folding (cyclophilins), cytoskeletal (CFL1, MYL12B, LSP1), translation (EIF3L), and mitochondrial (NDUFB7/11). PPIA is a classical housekeeping hub. The high mean expression (1.44) and 72% detection support a broadly active housekeeping program with cytoskeletal elements. Cyclophilins dominate — protein folding/housekeeping classification fits best.
Genes
B2M, BBLN, BCL7C, C12orf75, CFL1, EDF1, EIF3L, ERH, GTF3A, IL32, LSP1, MYL12B, NDUFB11, NDUFB7, PPIA, PPIB, PYURF, SMDT1, SSR2
Most correlated modules
- ER Glycosylation & Ubiquitin · correlation 0.88
- Antigen Processing · correlation 0.87
- Lymphocyte Trafficking · correlation 0.84
- ATP Synthase Complex · correlation 0.82
- NADPH Oxidase & Innate Immune · correlation 0.79
- Mitochondrial Metabolism & Redox · correlation 0.79
- RNA Biogenesis & Folding · correlation 0.79
- Actin Cytoskeletal Dynamics · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.