Antigen Processing
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Protein processing & ER |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes: CTDNEP1 (CTD nuclear envelope phosphatase), RAD23A (DNA repair/proteasome delivery), NCR3 (NKp30, natural cytotoxicity receptor — NK/MAIT activation marker), TMEM109 (ER membrane), PSMC5 (proteasome 26S AAA-ATPase), TMEM256 (transmembrane), TNFRSF25 (DR3, death receptor, TNF superfamily), CAPNS1 (calpain small subunit), NSA2 (ribosome biogenesis), SHISA5 (Scotin, pro-apoptotic ER protein), ATP5MJ (ATP synthase), SEC61G (ER translocon), PSME1 (proteasome activator PA28-alpha, antigen processing), AQP3 (aquaporin), PHB2 (prohibitin 2, mitochondria/ER), PPA1 (inorganic pyrophosphatase). The module combines proteasome/antigen processing (RAD23A, PSMC5, PSME1), ER components (SEC61G, TMEM109, SHISA5), death receptor signaling (TNFRSF25), and NCR3 (natural cytotoxicity). NCR3 and TNFRSF25 suggest immune activation/cytotoxic context. The proteasome/antigen processing component (RAD23A, PSMC5, PSME1) is prominent. This module likely represents antigen processing and presentation machinery co-expressed in cytotoxically active MAITs.
Genes
AQP3, ATP5MJ, CAPNS1, CCDC107, CTDNEP1, NCR3, NSA2, PHB2, PPA1, PSMC5, PSME1, RAD23A, SEC61G, SHISA5, TMEM109, TMEM256, TNFRSF25
Most correlated modules
- Cyclophilin-Mediated Folding · correlation 0.87
- Lymphocyte Trafficking · correlation 0.85
- ER Protein Glycosylation · correlation 0.85
- Cellular Housekeeping · correlation 0.84
- Mitochondrial Metabolism & Redox · correlation 0.83
- RNA Biogenesis & Folding · correlation 0.83
- Type I Interferon · correlation 0.82
- ATP Synthase Complex · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.