NADPH Oxidase & Innate Immune
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Inflammation |
|---|---|
| Genes | 18 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes include CYBA (p22phox — NADPH oxidase subunit, reactive oxygen species production), ATP5F1D (ATP synthase), NDUFA11/COX5A (Complex I/IV), ATP5MC3 (ATP synthase), TMSB10/TMSB4X (thymosin beta — G-actin sequestration), GABARAP (autophagy receptor), LAMTOR4 (Ragulator complex/mTORC1-lysosomal), RAC1 (Rho GTPase — NADPH oxidase assembly, actin), IFITM1/IFITM2 (interferon-induced transmembrane proteins — antiviral innate immunity), OAZ1 (ornithine decarboxylase antizyme — polyamine synthesis), HINT1 (histidine triad nucleotide binding). CYBA + RAC1 together constitute core NADPH oxidase components; IFITM1/2 add innate antiviral tone. ETC subunits are secondary. The co-expression of oxidative burst machinery (CYBA, RAC1) with IFITMs and actin dynamics suggests a basal innate immune/ROS-primed state in MAIT cells.
Genes
ATP5F1D, ATP5MC3, COX5A, CYBA, FXYD5, GABARAP, GNG5, HIGD2A, HINT1, IFITM1, IFITM2, LAMTOR4, NDUFA11, OAZ1, RAC1, SERF2, TMSB10, TMSB4X
Most correlated modules
- ER Glycosylation & Ubiquitin · correlation 0.88
- Immunoproteasome Activity · correlation 0.80
- Cyclophilin-Mediated Folding · correlation 0.79
- ATP Synthase Complex · correlation 0.73
- ER & Mitochondrial Assembly · correlation 0.72
- Cytotoxic Effector · correlation 0.72
- Cytotoxic Lymphocyte Program · correlation 0.69
- Translation Elongation · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.