HAX1 — HCLS1 associated protein X-1
HAX1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HAX1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | DNA damage response DNA/chromatin regulation | ATP2B1, CENPC, DEAF1, FBXO34, HECTD1, KMT5C, MRPL50, NDUFA5 +7 more | View in SCUBA |
| Gamma-delta T cells | Mitochondrial Housekeeping Mitochondrial & OxPhos | ARL2, BRAT1, C11orf58, CCDC115, CD3E, CHMP4A, CHURC1, DPM3 +13 more | |
| Innate lymphoid cells | Endosomal Trafficking Signaling Immune regulation | ARF1, CCDC85B, CKLF, COMMD8, FAM50A, GDE1, IL27RA, LSM8 +16 more | View in SCUBA |
| Mucosal-associated invariant T cell | ATP Synthase Complex Mitochondrial & OxPhos | ARL6IP4, ATP5F1E, ATP5ME, ATP5MK, COMMD6, COPS9, COX7C, NDUFA1 +3 more |
About the gene
| Synonyms | HAX-1, HCLSBP1, HS1BP1 |
|---|---|
| Chromosome | 1: 154272355-154275875 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
Function
Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.