ER & Mitochondrial Assembly
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Protein processing & ER |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 18 genes have a known function matching the annotation |
Why this annotation
RER1 (ER retention receptor for membrane protein quality control), VAMP8 (SNARE protein for vesicle fusion/secretion), TMBIM4 (transmembrane BAX inhibitor-1 motif, ER stress protection), SELENOH (nuclear selenoprotein), CSTB (cystatin B, lysosomal protease inhibitor), POLD4 (DNA polymerase delta small subunit), MRPS26 (mitoribosomal protein), ATP5MC1 (Complex V subunit), ANAPC11 (APC/C E3 ligase subunit), COA3 (cytochrome c oxidase assembly factor), DECR1 (mitochondrial fatty acid beta-oxidation), HINT2 (mitochondrial histidine triad), GSTK1 (mitochondrial glutathione transferase), YIF1A (Golgi/ER trafficking), ARRDC1 (arrestin domain, trafficking), TMEM223 (mitochondrial calcium uniporter regulator), S100A11 (calcium binding). The module integrates ER quality control, mitochondrial assembly, and vesicle trafficking — all housekeeping ER/mitochondrial functions.
Genes
ANAPC11, ARRDC1, ATP5MC1, COA3, CSTB, DECR1, GSTK1, HINT2, MRPS26, POLD4, PPP1R35, RER1, S100A11, SELENOH, TMBIM4, TMEM223, VAMP8, YIF1A
Most correlated modules
- Oxidative Stress Response · correlation 0.90
- T cell Identity · correlation 0.87
- Mitochondrial Biogenesis · correlation 0.87
- Cytotoxic Effector · correlation 0.84
- Mitochondrial Housekeeping · correlation 0.84
- T cell Homeostasis · correlation 0.81
- Leukocyte Housekeeping · correlation 0.80
- Cytotoxic Lymphocyte Program · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.