Chemokine Receptor Migration
Gene co-expression module in Mucosal-associated invariant T cell
| Category | migration & adhesion |
|---|---|
| Genes | 15 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 15 genes have a known function matching the annotation |
Why this annotation
The top hub genes are CCR5, CCR2, and CCR1 — three chemokine receptors central to leukocyte chemotaxis and migration, particularly to inflammatory sites. CD47 ('don't eat me' signal) supports immune cell survival/migration. VPS36 (ESCRT-II complex), SNX20 (sorting nexin), KRIT1 (cerebral cavernous malformation), UBXN4 (ubiquitin regulatory), PMS1 (mismatch repair), and PTGDR (prostaglandin receptor) are co-expressed. The presence of three CC-chemokine receptors as the top hubs strongly identifies this as a chemokine receptor / migratory module, consistent with MAIT cell tissue trafficking. Neighbor context: alongside M136 (which contains TNFAIP8/IRF2/GRAP2 immune signaling), this module likely reflects a chemotaxis arm of immune regulation in MAIT cells.
Genes
CCR1, CCR2, CCR5, CD47, FAM78A, KRIT1, LUC7L3, MTG1, PHF14, PMS1, PTGDR, SNX20, TMEM123, UBXN4, VPS36
Most correlated modules
- NF-κB Immune Survival · correlation 0.89
- Chromatin Maintenance State · correlation 0.88
- Nuclear regulatory housekeeping · correlation 0.87
- MAIT Effector Maturation · correlation 0.82
- Endosomal Actin Organization · correlation 0.82
- mRNA Export & Processing · correlation 0.78
- Oxidative Stress Response · correlation 0.76
- Mitochondrial Biogenesis · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.