Mitochondrial Biogenesis
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 24 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 24 genes have a known function matching the annotation |
Why this annotation
Multiple mitochondrial and metabolic genes dominate: NDUFB3 and NDUFA8 (NADH:ubiquinone oxidoreductase subunits, Complex I), SUCLG1 (succinyl-CoA ligase, TCA cycle), COA4 (cytochrome c oxidase assembly factor), MTIF3 (mitochondrial translation initiation factor), MRPL36 (mitoribosomal large subunit), ATP6V0E1 (vacuolar ATPase subunit). DBP is a PAR-domain bZIP transcription factor involved in circadian rhythm. The module reflects mitochondrial biogenesis and oxidative phosphorylation maintenance, with DBP potentially linking metabolic activity to circadian regulation.
Genes
ARFRP1, ARL2, ATP6V0E1, CALHM2, CCS, COA4, DBP, DENND2D, DMAC1, DPM3, HIKESHI, MED11, MRPL36, MTIF3, MTLN, NDUFA8, NDUFB3, NFYB, ORMDL2, SIT1, SUCLG1, TMEM250, TMEM35B, TWF2
Most correlated modules
- T cell Homeostasis · correlation 0.93
- T cell Identity · correlation 0.91
- MAIT Effector Maturation · correlation 0.90
- ER & Mitochondrial Assembly · correlation 0.87
- T cell Survival Regulation · correlation 0.87
- Actin Cytoskeletal Dynamics · correlation 0.85
- Oxidative Stress Response · correlation 0.84
- Mitochondrial Housekeeping · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.