Actin Cytoskeletal Dynamics
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Cytoskeletal |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes RAC2 (Rho GTPase critical for immune cell migration and cytoskeletal dynamics), CORO1A (coronin-1A, actin dynamics essential for T cell egress and migration), ACTG1 and ACTB (gamma- and beta-actin filaments), CSK (C-terminal Src kinase, negative regulator of LCK/cytoskeletal), TBC1D10C (Rab-GAP with roles in immune synapse), NHERF1 (ERM-scaffolding), SEPTIN1 (septin cytoskeletal), and CTSC (cathepsin C for cytotoxic granule processing) collectively define a cytoskeletal organization and lymphocyte motility module. Core coherence and uniform expression are consistent with a structural cytoskeletal program in MAIT cells.
Genes
ACTB, ACTG1, CLIC1, CORO1A, CSK, CTSC, NHERF1, PPP1CA, RAC2, SEPTIN1, TBC1D10C
Most correlated modules
- T cell Homeostasis · correlation 0.87
- Mitochondrial Biogenesis · correlation 0.85
- Immunoproteasome Activity · correlation 0.85
- T cell Survival Regulation · correlation 0.82
- Mitochondrial Metabolism & Redox · correlation 0.81
- Cyclophilin-Mediated Folding · correlation 0.78
- Lymphocyte Trafficking · correlation 0.78
- Mitochondrial Housekeeping · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.