T cell Homeostasis
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Housekeeping |
|---|---|
| Genes | 23 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 23 genes have a known function matching the annotation |
Why this annotation
Hub genes include LCK (core T cell signaling kinase), FERMT3 (kindlin-3, integrin activation in hematopoietic cells), ICAM2 (lymphocyte adhesion), PDCD6 (calcium-binding apoptosis-linked), PDLIM2 (cytoskeletal scaffold in T cells), TRADD (TNFR signaling), LAMTOR2 (mTOR/lysosomal), with metabolic genes ATP5PB and SDHC. The module is highly coherent and uniformly expressed, combining core T cell identity/signaling genes (LCK, FERMT3, ICAM2) with housekeeping metabolic and structural genes. LCK and FERMT3 are strong anchors for T cell-specific housekeeping/basal signaling maintenance rather than an activation state.
Genes
ATP5PB, COPZ1, FERMT3, GPS1, HMGN4, ICAM2, LAMTOR2, LCK, LSM6, MRPL20, MRPL24, PDCD6, PDLIM2, PHB1, PPP1R18, PSMD4, RGS19, RNF167, RPA2, SDHC, SNX17, TEX264, TRADD
Most correlated modules
- Mitochondrial Biogenesis · correlation 0.93
- MAIT Effector Maturation · correlation 0.91
- Mitochondrial Housekeeping · correlation 0.90
- T cell Identity · correlation 0.87
- Actin Cytoskeletal Dynamics · correlation 0.87
- TCR Signaling Identity · correlation 0.86
- T cell Surface Signaling · correlation 0.84
- Leukocyte Housekeeping · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.