Immunoproteasome Activity
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Inflammation |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
PSMB9 and PSMB10 are the defining immunoproteasome subunits (beta1i and beta2i), strongly induced by IFN-γ and central to antigen presentation. ARPC5 (Arp2/3 actin nucleation), ABRACL (actin dynamics), BANF1 (chromatin/nuclear envelope barrier after division), CARD16 (caspase-1 decoy, inflammation), GIMAP2 (T cell GTPase survival), TRAPPC1 (vesicle trafficking), TALDO1 (pentose phosphate pathway), CISD3 (mitochondrial iron-sulfur), PLAAT4 (phospholipase A), and IMP3 (U3 snoRNP). The immunoproteasome hub is the dominant biological signal; additional genes support immune cell homeostasis. Core coherence supports a unified program.
Genes
ABRACL, ARPC5, BANF1, CARD16, CISD3, CYBC1, GIMAP2, IMP3, PLAAT4, PSMB10, PSMB9, TALDO1, TRAPPC1
Most correlated modules
- Mitochondrial Metabolism & Redox · correlation 0.89
- RNA Biogenesis & Folding · correlation 0.88
- Actin Cytoskeletal Dynamics · correlation 0.85
- Mitochondrial Ribosome · correlation 0.83
- ER Glycosylation & Ubiquitin · correlation 0.83
- Mitochondrial OxPhos · correlation 0.83
- Type I Interferon · correlation 0.81
- Lymphocyte Trafficking · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.