AP-1/MEF2 Activation
Gene co-expression module in Mucosal-associated invariant T cell
| Category | T cell maturation |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 17 genes have a known function matching the annotation |
Why this annotation
Top hub genes MEF2D and FOSL2 (AP-1 component) are key transcription factors in T cell activation and chronic stimulation. BHLHE40 is a bHLH repressor induced during T cell activation and exhaustion. NR1D2 is a circadian nuclear receptor. GADD45A is a stress/DNA damage response gene. MAP2K7 activates JNK signaling. GSPT1 is involved in translation termination. DBF4 and CDK16 suggest mild cell cycle activity. Neighbor to M119 (NF-κB), supporting a complementary AP-1/MEF2 transcriptional activation program co-occurring with NF-κB signaling in MAIT activation.
Genes
ADNP2, BHLHE40, CDK16, DBF4, ETF1, FOSL2, GADD45A, GPR35, GSPT1, JOSD1, MAP2K7, MEF2D, NR1D2, OSER1, RBM38, TAMALIN, TXNDC11
Most correlated modules
- Stress Granule Response · correlation 0.92
- NF-κB Activation · correlation 0.90
- mRNA Decay Program · correlation 0.89
- RNA Processing Stress · correlation 0.89
- Autophagy & Trafficking · correlation 0.89
- NF-κB Negative Feedback · correlation 0.87
- T cell Quiescence · correlation 0.87
- Post-translational Regulation · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.