RALGDS — Ral guanine nucleotide dissociation stimulator
RALGDS belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RALGDS's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | TNF/NF-kB response BCR/AP1/NFKb pathway | ADGRE5, ATF3, BHLHE40, CHD1, CMTM6, CYLD, DUSP5, FMNL1 +7 more | View in SCUBA |
| CD4⁺ T cells | Integrin Rap1 Signaling migration & adhesion | ARL3, ATP2B4, ATXN1, DR1, GDE1, GNA15, GRAMD1B, GTDC1 +8 more | View in SCUBA |
| Endothelial | Inflammatory Angiogenesis Endothelial cell development | FAM241A, FAM43A, KLF6, MYC, NFATC1, PHLDA1, PIM3, PLEKHO2 +7 more | View in SCUBA |
| Gamma-delta T cells | TGF-beta Response Immune regulation | ADGRE5, CD83, CHMP1B, CHST7, DDIT3, DNAAF2, EHD4, FAM43A +15 more | |
| Monocytes | Integrin-mediated Migration Migration & adhesion | DNAAF1, EIF4E, ITGA5, ITGB8, LMNA, MSC, NRIP3, PHLDA1 +7 more | View in SCUBA |
| Mucosal-associated invariant T cell | Retinoic Acid Response Tissue residence | C16orf54, CHRAC1, EHD1, MRPL10, NDRG1, PERP, RARA | |
| Pericytes | EMT-like Remodeling ECM remodeling | APOLD1, B3GNT5, C2CD4B, CFAP20, FAM43A, INSIG1, LDLR, RND1 +2 more | View in SCUBA |
About the gene
| Synonyms | RalGEF, RGDS, RGF |
|---|---|
| Chromosome | 9: 133097720-133149334 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, RAS pathway related proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
Functions as a guanine nucleotide exchange factor (GEF) activating either RalA or RalB GTPases and plays an important role in intracellular transport. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap (By similarity). During bacterial clearance, recognizes 'Lys-33'-linked polyubiquitinated TRAF3 and subsequently mediates assembly of the exocyst complex.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.