Epigenetic Chromatin Regulation
Gene co-expression module in Mucosal-associated invariant T cell
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
CREBBP (CBP, histone acetyltransferase and master transcriptional coactivator), GATAD2A (NuRD repressor complex), ASXL1 (Polycomb-associated chromatin regulator), RYBP (PRC1 component), and ZSWIM6 reflect a mixed chromatin activation/repression regulatory module. RAPGEF1 connects to TCR-downstream RAS/RAP signaling. FNIP1 (FLCN interactor) links to mTORC1/AMPK metabolic sensing. PELI1 (E3 ligase in NF-κB pathway) and PNRC1 (mRNA decay) are peripheral. The module likely captures epigenetic regulatory machinery active in resting or post-activation MAIT cells.
Genes
ASXL1, CREBBP, FNIP1, GATAD2A, PELI1, PNRC1, RAPGEF1, RYBP, ZCCHC2, ZSWIM6
Most correlated modules
- Hypoxia-ER Stress · correlation 0.81
- NF-κB Activation · correlation 0.81
- Transcriptional Repression · correlation 0.79
- T cell Quiescence · correlation 0.79
- Nuclear-Cytoplasmic Transport · correlation 0.77
- Post-translational Regulation · correlation 0.75
- Transcriptional Co-regulation · correlation 0.75
- TCR Signal Attenuation · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.