WDR26 — WD repeat domain 26
WDR26 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
WDR26's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Ubiquitin-p53 Regulation Protein processing & ER | ATXN7, CCNL1, DCTN4, FNBP1, HERPUD2, MOB4, RBBP6, RNF139 +4 more | |
| Macrophages | RAB-mediated Trafficking Vesicular traficking | ABI1, ACSL3, ARMC8, CACUL1, CD86, CHST15, CRTC3, CTNNA1 +27 more | View in SCUBA |
| Mucosal-associated invariant T cell | Transcriptional Co-regulation DNA/chromatin regulation | ALYREF, CCNT1, CSNK1E, FBXO7, MXRA7, PLEKHM2, PLXND1, TADA2B +1 more | |
| Neutrophils | Ubiquitin-Proteasome Turnover Housekeeping | BLTP3B, CACUL1, CLIP1, FBXL20, FBXO33, FGD3, IL18RAP, KIF13A +10 more |
About the gene
| Synonyms | FLJ21016, GID7 |
|---|---|
| Chromosome | 1: 224385146-224437033 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
Function
G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation. Serves as a scaffold to coordinate PI3K/AKT pathway- driven cell growth and migration. Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria. Also protects cells by promoting hypoxia-mediated autophagy and mitophagy (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.