NF-κB Activation
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Inflammation |
|---|---|
| Genes | 17 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 13 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes include PER1 (circadian), RELB, NFKB1, REL (NF-κB family), TRAF4 (NF-κB signaling), PIM3 (pro-survival kinase downstream of cytokines), MAFF (stress bZIP), DUSP5/DUSP8 (MAPK phosphatases), GABARAPL1 (autophagy), NAMPT (NAD/inflammatory mediator), TIPARP (stress PARP), and IRF2BP2 (NF-κB repressor). The module is dominated by NF-κB transcription factors and their direct targets, with secondary stress/metabolic components. All genes are core members with uniform expression, indicating a broad T cell activation-linked NF-κB transcriptional program.
Genes
DUSP5, DUSP8, ELL2, GABARAPL1, IRF2BP2, MAFF, NAMPT, NFKB1, PER1, PIM3, REL, RELB, SLC7A5, SRGN, TIPARP, TRAF4, ZNF331
Most correlated modules
- Stress-Induced Growth Arrest · correlation 0.91
- T cell Quiescence · correlation 0.91
- AP-1/MEF2 Activation · correlation 0.90
- cAMP Immune Regulation · correlation 0.90
- NF-κB Negative Feedback · correlation 0.89
- RNA Processing Stress · correlation 0.89
- Stress Granule Response · correlation 0.87
- Transcriptional Co-regulation · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.