Lymphocyte Migration
Gene co-expression module in Mucosal-associated invariant T cell
| Category | migration & adhesion |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 17 genes have a known function matching the annotation |
Why this annotation
DOCK2 is a canonical Rac1 GEF essential for lymphocyte chemotaxis and migration. DOCK11 activates Cdc42, also involved in cytoskeletal remodeling. LPP is a LIM domain protein at focal adhesions. BIRC6 is an anti-apoptotic ubiquitin ligase. PRKDC (DNA-PKcs) is involved in DNA repair. CEP350 is a centrosomal protein. SCAPER regulates S-phase cyclin A. RABGAP1L, AP3B1 mediate vesicular trafficking. ERBIN is a scaffold. SLFN12L is a SLFN family immune regulator. The dominant theme is lymphocyte migration and cytoskeletal organization driven by DOCK2 and DOCK11, with supporting roles in vesicle trafficking and survival. Neighbor M60 also shows broad homeostatic regulation, consistent with this being a related lymphocyte maintenance/migratory module.
Genes
AP3B1, ATP9B, BIRC6, BTBD9, CEP350, DOCK11, DOCK2, ERBIN, FRYL, INPP4B, LPP, PRKDC, RABGAP1L, SCAPER, SLFN12L, TMEM131, ZNF148
Most correlated modules
- RAS-GEF Signaling · correlation 0.91
- Calcineurin-NFAT Signaling · correlation 0.90
- Cytoskeletal Migration · correlation 0.88
- Chromatin Remodeling · correlation 0.88
- SWI/SNF Chromatin Remodeling · correlation 0.86
- T cell Homeostasis · correlation 0.84
- Immune Synapse Signaling · correlation 0.83
- Cytoskeletal Migration · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.