TCR Signaling Identity
Gene co-expression module in Mucosal-associated invariant T cell
| Category | TCR Signaling |
|---|---|
| Genes | 19 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 19 genes have a known function matching the annotation |
Why this annotation
Top hub genes ZAP70 and CD3G are core TCR signaling components. ZBTB7A (LRF) is a critical T cell lineage transcription factor. RASAL3 regulates RAS/MAPK downstream of TCR. IL27RA integrates cytokine signals with TCR activation context. ACAP1 (ACAP1/centaurin) is involved in TCR-mediated integrin regulation. TSC22D4 and RASSF1 modulate downstream signaling. The coherent co-expression of TCR complex (CD3G) and proximal kinase (ZAP70) with lineage TFs defines a TCR signaling identity module.
Genes
ACAP1, CASP4, CD3G, CENPT, CFAP97, DPP7, FBXW5, IL27RA, LMF2, PARVG, RASAL3, RASSF1, RGL2, SHISAL2A, TMC8, TRIM8, TSC22D4, ZAP70, ZBTB7A
Most correlated modules
- MAIT Effector Maturation · correlation 0.87
- T cell Homeostasis · correlation 0.86
- Cytoskeletal Remodeling Migration · correlation 0.84
- IL-12 Cytotoxic Effector · correlation 0.84
- Mitochondrial OxPhos · correlation 0.84
- Mitochondrial Housekeeping · correlation 0.82
- T cell Surface Signaling · correlation 0.82
- T cell Identity · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.