TSC22D4 — TSC22 domain family member 4
TSC22D4 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TSC22D4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Lymphocyte Homeostatic Regulation Housekeeping | BSG, CTDSP1, FBXW5, HMGN4, IGSF8, IKBKG, LRP10, MFNG +8 more | |
| Innate lymphoid cells | JAK-STAT Cytokine Signaling Inflammation | AASDHPPT, ARHGAP9, CHURC1, CIDEB, CSK, DCAF7, DENND2D, EDEM2 +23 more | View in SCUBA |
| Mucosal-associated invariant T cell | TCR Signaling Identity TCR Signaling | ACAP1, CASP4, CD3G, CENPT, CFAP97, DPP7, FBXW5, IL27RA +10 more |
About the gene
| Synonyms | THG-1, TILZ2 |
|---|---|
| Chromosome | 7: 100463359-100479232 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Binds DNA and acts as a transcriptional repressor. Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release. May play a role in neurite elongation and survival (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.