cAMP Immune Regulation
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Immune regulation |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
CREM is a cAMP-responsive transcription factor known to suppress T cell activation and is a key regulator downstream of TCR/cAMP signaling. PDE4B is a phosphodiesterase that degrades cAMP, modulating immune cell activation. MAPKAPK2 (MK2) is a p38 MAPK substrate involved in inflammatory and stress signaling. JMJD6 is a histone arginine demethylase with roles in RNA splicing and transcription. USP36 is a deubiquitinase. SNX9 regulates membrane trafficking/endocytosis. SYAP1 and FAM177A1 are less characterized. Together, CREM and PDE4B point to a cAMP-mediated immunoregulatory program, with p38/MAPKAPK2 as a stress-signaling component.
Genes
CREM, FAM177A1, JMJD6, MAPKAPK2, METRNL, PDE4B, SNX9, SYAP1, USP36
Most correlated modules
- NF-κB Activation · correlation 0.90
- T cell Quiescence · correlation 0.88
- Rho GTPase Migration · correlation 0.81
- NF-κB Activation · correlation 0.80
- Stress-Induced Growth Arrest · correlation 0.80
- Splicing Regulation · correlation 0.80
- AP-1/MEF2 Activation · correlation 0.80
- Stress Granule Response · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.