SYAP1 — Synapse associated protein 1

SYAP1 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SYAP1's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Immediate early activation TCR/AP1/NFKb pathway	ALG13, AREG, BCAS2, C9orf72, CXCR4, FAM222A, HIP1R, NR4A2 +18 more	View in SCUBA
Gamma-delta T cells	Late Activation Autophagy Immune regulation	BCL3, BRD1, CREM, DUSP8, FAM177A1, FBXO33, FOSL2, GABARAPL1 +19 more
Innate lymphoid cells	Prostaglandin-AP1 Response Inflammation	ARIH1, ARL5B, CCNT1, CHD1, CXCL2, ETV3, FOSL2, IRF2BP2 +12 more	View in SCUBA
Macrophages	Autophagy Vesicle Trafficking Lysosomal & pahgocytosis	ADNP2, AGO2, AP1G1, ARFGAP3, ATG2A, BANP, CHD1, CHD2 +26 more	View in SCUBA
Monocytes	Wnt/AP-1 Activation Inflammatory	B4GALT1, BZW1, CHD1, CTNNB1, ETF1, FOSL2, GABARAPL1, GPCPD1 +2 more	View in SCUBA
Mucosal-associated invariant T cell	cAMP Immune Regulation Immune regulation	CREM, FAM177A1, JMJD6, MAPKAPK2, METRNL, PDE4B, SNX9, USP36
Natural Killer cells	MAPK/AP-1 Signaling Inflammation	B3GNT7, BRAF, FAM177A1, FOSL2, GPBP1, PDE4B, PIK3R1, RALGAPA1 +4 more	View in SCUBA
Neutrophils	NF-κB Inflammatory Transcription Inflammatory	BID, C9orf72, DENND5A, ELL2, ETF1, N4BP1, NFE2L2, NFKB1 +10 more

About the gene

Synonyms	FLJ14495, PRO3113
Chromosome	X: 16719612-16765340
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins
Biological process	Differentiation

Function

Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.